The first PMDA-approved METex14 companion diagnostic
Archer®MET is the first PMDA-approved METex14 companion diagnostic for NSCLC
ArcherMET tests for MET exon 14 (METex14) skipping mutations in non-small cell lung cancer (NSCLC) to identify patients who may benefit from new PMDA-approved targeted therapies.
METex14 skipping: An important biomarker for therapy selection
A new targeted therapy was approved by the PMDA for NSCLC patients with METex14 alterations, which is why it’s important to know every patient’s status.
Prevalence of select NSCLC Oncogenic Alterations1-11
- METex14 skipping mutations lead to oncogenic MET signaling, resulting in poor prognosis.12
- Deregulation of the MET pathway via MET mutations plays an important role in acquired resistance to EGFR-TKIs.13
- METex14 skipping is associated with poor response to standard NSCLC therapies.14-18
There is now a new PMDA-approved targeted therapy for NSCLC patients with METex14 skipping
With ArcherMET, you can test for METex14 skipping mutations in NSCLC patients using tissue and blood samples
As a test kit with a simple workflow for testing tissue and liquid biopsies, ArcherMET can be easily added to any NSCLC diagnostic workflow.
Expand your NSCLC testing workflow with ArcherMET
Reliable results you can trust
ArcherMET leverages proprietary Anchored Multiplex PCR (AMP™) technology that can efficiently and accurately detect METex14 skipping mutations by sequencing RNA from tissue and ctDNA from blood.
*At 3.0% allele frequency using 5 ng ctDNA and 0.3% allele frequency using 30 ng ctDNA and 10 ng RNA.
Minimal sample requirements that ensure patient access to testing
- Minimum 2 unstained FFPE slides
- 5-10 um thickness per slide
- Minimum 20mm2 tissue (the total area of the tissue should be determined from H&E)
- Nucleic acid content: >10 ng TNA
- 10 mL whole blood
- Nucleic acid content: >5 ng ctDNA
- No need for invasive tissue biopsy
Identify METex14-positive patients with ArcherMET so your NSCLC patients can receive effective therapy sooner
How to order
ArcherMET is available for order through LSI Medience and SRL For instructions on to order and prepare samples, please contact each lab directly:
Learn more about ArcherMET by emailing us at the button below.
ArcherMET is only available for companion diagnostic use in Japan
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